Inhibition of the p38 MAPK pathway sensitises human colon cancer cells to 5-fluorouracil treatment
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چکیده
منابع مشابه
Nicotinamide N-methyltransferase enhances resistance to 5-fluorouracil in colorectal cancer cells through inhibition of the ASK1-p38 MAPK pathway
Nicotinamide N-methyltransferase (NNMT), which converts nicotinamide to 1-methylnicotinamide (1-MNA), is overexpressed in a variety of human cancers and serves as a potential anti-cancer target. In this study, we investigated the effect of NNMT on 5-fluorouracil (5-FU) sensitivity of colorectal cancer (CRC) cells, and the underlying mechanisms. Our results show that down-regulation of NNMT in C...
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ژورنال
عنوان ژورنال: International Journal of Oncology
سال: 2011
ISSN: 1019-6439,1791-2423
DOI: 10.3892/ijo.2011.982